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Accumulating Spike Protein Threatens the Health of Billions - America Out Loud
As the months and years wear on in the COVID-19 pandemic crisis, it is becoming increasingly evident that both with the respiratory infection caused by SARS-CoV-2 coronavirus and with repeated and frequent systemic administrations of COVID-19 vaccines that, the human body is being loaded with coronavirus Spike protein.
In the medical literature, terms such as “Spike protein disease,” “Spikopathy,” and “Spike prion-like illness” are appearing. With a size of 180–200 kDa, the Spike protein consists of an extracellular N-terminus, a transmembrane domain anchored in the viral membrane, and a short intracellular C-terminal segment.1
The Spike protein normally exists in a metastable, prefusion conformation; once the virus engages the human ACE-2 receptor, extensive structural rearrangement of the Spike protein occurs, allowing the virus to fuse with the host cell membrane. The spikes are coated with polysaccharide molecules to camouflage them, evading surveillance of the host immune system during entry into the body.
The total length of the Spike protein is 1273 amino acids and consists of a signal peptide (amino acids 1–13) located at the N-terminus, which is cleaved, the S1 subunit (14–685 residues), and the S2 subunit (686–1273 residues); the last two regions are responsible for receptor binding and membrane fusion, respectively. In the S1 subunit, there is an N-terminal domain (14–305 residues) and a receptor-binding domain (319–541 residues); the fusion peptide (FP) (788–806 residues), heptapeptide repeat sequence 1 (912–984 residues), heptapeptide repeat sequence 2 (1163–1213 residues), transmembrane domain (1213–1237 residues), and cytoplasm domain (1237–1273 residues) comprise the S2 subunit.
Spike protein trimers visually form a characteristic bulbous, crown-like halo surrounding the viral particle structure of the SARS-CoV-2 trimeric S protein has been determined by cryo-electron microscopy at the atomic level to be dynamic and take on conformations at different phases of viral action. Far less is described in the literature on the Spike protein that is produced from mRNA and adenoviral DNA vaccines, which billions of persons have taken into their bodies across the globe.
Based upon what is known, the COVID-19 vaccine-produced Spike protein carries with it at least as much pathogenicity, if not more than the Spike protein that is on the surface of an intact SARS-CoV-2 virion.
In this weeks Report, Dr Jean-François Lesgards, Laboratoire Sondes Moléculaires en Biologie et Stress Oxydant, Institut de Chimie Radicalaire, Aix Marseille Université, Marseille, France, does a deep dive on this protein that is now apart of so many lives in this post-COVID-19 vaccine world.2
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2 https://www.linkedin.com/in/jflesgards/?originalSubdomain=fr
