KEY POINTS:
A citywide prevention program using ivermectin as prophylaxis for COVID-19 was implemented in Itajaí, a southern city in Brazil in the state of Santa Catarina between July 2020 and December 2020.
According to this comprehensive study, the regular use of ivermectin as a prophylactic agent was associated with significantly reduced COVID-19 infection, hospitalization, and death rates.
The ivermectin non-users were two times more likely to die of COVID-19 than ivermectin users in the overall population analysis.
... for the 6,068 subjects (3,034 in each group), there were 44 hospitalizations among ivermectin users (1.6% hospitalization rate) and 99 hospitalizations (3.3% hospitalization rate) among ivermectin non-users, a 56% reduction in hospitalization rate.
When adjustment for variables was employed, the reduction in hospitalization rate was 67%
There were 25 deaths among ivermectin users (0.8% mortality rate) and 79 deaths among non-ivermectin users (2.6% mortality rate), a 68% reduction in mortality rate
... In this citywide ivermectin prophylaxis program, a large, statistically significant decrease in mortality rate was observed after the program began among the entire population of city residents.
When comparing subjects that used ivermectin regularly, non-users were two times more likely to die from COVID-19 while ivermectin users were 7% less likely to be infected with SARS-CoV-2
Although this study is not a randomized, double-blind, placebo-controlled clinical trial, the data were prospectively collected and resulted in a massive study sample that allowed adjustment for numerous confounding factors, thus strengthening the findings of the present study.
Due to the well-established, long-term safety profile of ivermectin, with rare adverse effects, the absence of proven therapeutic options to prevent death caused by COVID-19, and lack of effectiveness of vaccines in real-life all-cause mortality analyses to date ...
Cite this article as:
Kerr L, Cadegiani F A, Baldi F, et al. (January 15, 2022) Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching"
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Friday, January 28, 2022
Itajaí, Brazil Citywide Prevention Program using Ivermectin Significantly Reduced COVID-19 Infection, Hospitalization, and Mortality Rate
FULL ARTICLE IS HERE: